![]() The story follows Takaaki Kouno's daily life in high school alongside his childhood friends Konomi Yuzuhara (who just graduated from middle school) and Tamaki Kousaka. It is a sequel/spin-off series of sorts to To Heart it is set in the same universe, albeit two years later with a completely new set of characters. 13 Although criteria are evolving, the Dallas criteria require “inflammatory infiltrates of the myocardium with necrosis and/or degeneration of adjacent myocytes, not typical of ischemic damage associated with coronary artery disease.To Heart 2 is a Japanese Visual Novel developed by Leaf. In the acute/active phases, it is usually accompanied by myocyte damage/necrosis. 13 Lymphocytic myocarditis is the commonest histologic subtype, characterized by an inflammatory myocardial infiltrate typically comprising mononuclear cells. Noninfectious causes include immune/autoimmune conditions (autoantigens, association with immune-mediated diseases, alloantigens, and allergens), drugs/toxic substances (eg, hypersensitivity or direct toxic effects), and other causes (eg, radiation, insect stings, snake bites). ![]() 13 The etiologies are varied and include infectious and noninfectious causes. Myocarditis is an inflammatory disease of the myocardium, which may occur in isolation or as part of multiorgan/systemic immune-mediated disorders or reactions to exogenous/endogenous substances.
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